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【TargetMol】L9800 CRBN Molecular Glues Library from TargetMol

  • 2025/07/28
  • サプライヤニュース

新着情報一覧へ

 

Now Live: L9800 CRBN Molecular Glues Library from TargetMol

 

The CRBN Molecular Glues Library is developed based on a deep understanding of drug discovery, innovative data integration approaches, and strong software and engineering capabilities. It features reliable CRBN warhead design to enhance the efficiency and success rate of identifying CRBN-targeted molecular glue drugs.
This library contains 1,771 newly synthesized CRBN-targeted molecular glue compounds, with molecular weights ranging from 250 to 700. These compounds exhibit good structural diversity and complexity.

 

Product Features
1. A total of 1,771 newly designed and synthesized molecular glue structures for use in research on CRBN-targeting molecular glue drugs;
2. CRBN warheads with validated literature support were selected, and high-reliability potential CRBN-targeting molecular glues were designed through an AI-based molecular generation and optimization system;
3. In addition to lenalidomide-like structures, various non-lenalidomide-based spirocyclic scaffolds are included, offering opportunities for novel scaffold discovery;
4. Optimized for structural diversity and drug-like properties, these compounds demonstrate good structural representation and druggability;
5. Small-scale random screening has shown a significantly higher success rate compared to CRBN ligand molecules from other commercial sources.

The Library Construction Process

   

Collect reliable CRBN ligands based on literature and patents.

 

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Select core scaffolds with binding affinity from an AI-designed molecular database, and choose several series of derivatives.

 
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Filter out bridged fragment molecules that may have structural conflicts with CRBN.
 
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Physicochemical Properties: Exhibits good scaffold diversity and drug-like properties.
 
   
 

Examples of Structures

Pilot Validation
A small-scale screening of 242 compounds from the library was conducted to evaluate the screening reliability. After repeated rounds of verification, 10 reproducible hit compounds were identified, demonstrating the library's potential for hit discovery.
  Left:242 compounds Ternary point screening_SPS—56hits
Right: Ternary DRC _HTRF—10 hits

Comparative Validation

Using TargetMol's CRBN molecular glue library significantly improved the hit rate of CRBN molecular glue screening.

Left: Rationally designed and synthesized CRBN molecular glue library screening
Right: Other commercially sourced molecules containing CRBN warheads

 

CONTACT US!
 
If you are interested in L9800 CRBN Molecular Glues Library and get information on our more products,please visit our website:https://www.targetmol.com or contact us at sales@targetmol.com for possible discounts!
 
 
 
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TargetMol(ターゲットモル)社について

本社所在地
アメリカ マサチューセッツ州
URL
https://www.targetmol.com/

TargetMolは、ボストンに本社を置く低分子およびスクリーニングライブラリのサプライヤです。ライフサイエンス試薬、阻害剤、活性剤、実験用および科学用の天然化合物を提供しています。ポートフォリオには、6,000を超える化合物/阻害剤(カタログ)と80種類を超える化合物ライブラリがあります。

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