【ACRO Biosystems】毒性試験向けのオルガノイドソリューション

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【ACRO Biosystems】毒性試験向けのオルガノイドソリューション

2025/06/30
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医薬品開発において、医薬品の安全性を確保するために不可欠です。生理学的活性のある3Dモデルであるオルガノイドは、従来の方法よりも正確な検証ができます。以下では、医薬品の安全性評価におけるオルガノイドを用いた毒性試験の事例を紹介します。

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毒性試験向けの脳オルガノイド

Cardiac Organoids (Cat. No. CIPO-HWL002K) have showed a good tendency in the ECG signal from Microelectrode Array (MEA) platform to respond to positive drugs exactly as expected from the drug principle.

Dofetilide

hERG K⁺ channel inhibitors induce QT interval prolongation.

Nifedipine

Ca²⁺ ion channel inhibitors induce QT interval shortening.

毒性試験向けの脳オルガノイド

Cerebral Organoids (Cat. No. CIPO-BWL002K) were treated with increasing concentrations of NMDA to assess excitotoxicity. Cellular responses were evaluated using specific markers.

NMDA induced dose-dependent cell damage, evidenced by reduced numbers of neurons (MAP2+) and neural stem cells (SOX2+), along with increased Caspase-3 activity (an apoptosis marker) and LDH release (an indicator of membrane damage and cytotoxicity). Compared to 2D-cultured SH-SY5Y cells, cerebral organoids exhibited greater resistance to excitotoxic stress.

毒性試験向けの肝臓オルガノイド

Troglitazone, known to cause liver toxicity, was applied to Liver Organoids (Cat. No. CIPO-RWL005K). Acridine Orange/Propidium Iodide (AO/PI) staining is a common method to assess cell viability and death, distinguishing live (green) from dead cells (red).

The liver organoids in the Troglitazone-treated group showed a higher number of dead cells, and the fluorescence signal intensity increased progressively with longer drug exposure.

毒性試験向けの腸管オルガノイド

Intestinal Organoids (Cat. No. CIPO-IWL003K) differentiated using the Intestinal Organoid Differentiation Kit (Cat. No. RIPO-IWM005K) were treated with Abemaciclib to evaluate its impact on epithelial barrier function.

Abemaciclib altered transepithelial electrical resistance (TEER) in intestinal organoids. Low doses temporarily increased TEER, but levels dropped by day 5. High doses caused a continuous decline, indicating epithelial toxicity. ZO-1 and ECAD staining showed disruption of tight junction and epithelial cell, while SOX9+ stem cells were almost unaffected. These suggest barrier dysfunction, potentially leading to leakage, pathogen entry, and inflammation.

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Mogengel Matrix for Organoid Culture

Cytokines for Organoid Culture

Organs-on-Chips

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ACRO Biosystems(アクロバイオシステムズ)社について

ACRO Biosystems(アクロバイオシステムズ)

設立: 2010年
本社所在地: 中国北京
URL: https://www.acrobiosystems.com

ACROBiosystemsは2010年に設立された国際的なバイオテクノロジー企業です。
生物医学やヘルスケアの分野で分子生物学用試薬や様々なサービスを提供するプラットフォーム型の企業であり、中国、アメリカ、ヨーロッパなどの生産拠点から世界中の国や地域で世界トップクラスの医薬品企業を含む5000以上のお客様にタンパク質、抗体、キットなどの製品と分析サービスを提供しています。これらの製品は、サービスは主にがん、免疫疾患、心血管疾患、感染症などに使用される医薬品のスクリーニングや前臨床試験、医薬品製造、プロセス制御(CMC)、診断薬開発/最適化などにご利用いただけます。
2021年には中国深圳証券取引所へ上場も果たしており、成長を続けている会社です。

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