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MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
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• Over 100,000 bioactive molecules in stock
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• Target 10,000+ key proteins in 20+ signaling pathways
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• Quality reports (LC/MS, NMR and HPLC) for each product
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• Release more than 1,000 latest biochemicals per month
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• Data sheet with detailed biological information
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• High purity & competitive prices
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• Delivery within 24 hours
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CAS No.: 2131210-15-4
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Research Area: Molecular Glues/Phosphodiesterase (PDE)/Gastrointestinal Stromal Tumor
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A molecular glue to induce complex formation between PDE3A and Schlafen family member 12 (SLFN12).
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Leads to SLFN12 RNase-mediated cell death.
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Used for the research of advanced gastrointestinal stromal tumors (GISTs).
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Solubility: DMSO: 125 mg/mL (400.24 mM; Need ultrasonic)
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CAS No.: 2361332-90-1
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Research Area: Apoptosis/Reactive Oxygen Species (ROS)/Colorectal Cancer
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An orally active SRSF3 inhibitor with potent antitumor efficacy.
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Drives apoptosis of colorectal cancer (CRC) cells via the SRSF3/DHCR24/reactive oxygen species (ROS) axis.
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Solubility: DMSO: 125 mg/mL (343.94 mM; Need ultrasonic)
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CAS No.: 2446767-14-0
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Research Area: TDP1/Cancer
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An orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM.
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Enhances the clastogenic and anti-tumor effects of Topotecan in vivo.
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Solubility: DMSO: 25 mg/mL (63.70 mM; Need ultrasonic and warming and heat to 60°C)
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MCE Peptides
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Structural
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Product Name
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Description
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vMIP-II (1-21) TFA
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A CXCR4 antagonist with broad-spectrum interaction with CC and CXC chemokine receptors.
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Cdk5i peptide
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A 12-mer peptide, and is a Cdk5/p25 inhibitor.
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MCE Natural Products
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Staphylococcus aureus is the most common pathogen causing hospital infections. With the emergence and rapid spread of the "superbug" methicillin-resistant Staphylococcus aureus (MRSA), there is an urgent need to discover new superbugs in clinical practice to address the threat of superbugs.
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Product Name
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Description
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Sanguisorbigenin
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A natural antibacterial agent that inhibits MRSA.
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Salvinolone
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Active against MRSA and vancomycin-resistant Enterococcus (VRE).
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Deoxyshikonin
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An antibacterial agent against MRSA and S. pneumonia (MIC=17 μg/mL).
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Schisandrone
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An alpha-hemolysin (Hla) inhibitor, and a potent inhibitor against MRSA pneumonia.
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Celastrol
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Combats MRSA by targeting Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH).
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MCE Compound Library
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Provide professional compound library, serving cancer, immunity, metabolism and other fields of research.
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Product Name
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Description
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RO5 Drug-like Natural Product Library
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Lipinski rule of 5 (Lipinski rule of 5) is used to describe the properties of a molecule-like drug. Based on the existing library of natural products, MCE selects 2,700+ molecules that meet the five principles of Lipinski, which can further accelerate the screening efficiency.
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Latest Publications Citing Use of MCE Products
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Nature.
2024 Sep;633(8031):895-904.
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Nature.
2024 Sep;633(8031):932-940.
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Cell.
2024 Sep 19;187(19):5238-5252.e20.
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Cell.
2024 Oct 17;187(21):6016-6034.e25.
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