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MedChemExpress (MCE) provides a wide range of life-science biochemicals, including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com.
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CAS No.: 2938995-50-5
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Research Area: Epigenetic Reader Domain/Menin-MLL/Acute Leukemias
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A highly selective and orally active menin-MLL inhibitor.
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Shows very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant.
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Has optimized drug-like properties and excellent efficacy in MV4-11 xenograft mouse model.
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Solubility: DMSO: 100 mg/mL (175.24 mM; Need ultrasonic)
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CAS No.: 2540881-21-6
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Research Area: RIP kinase/RIPK3/Lung Inflammation
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A potent and selective RIPK3 inhibitor with an IC50 value of 20 nM.
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Selectively blocks IAV (influenza A virus)-triggered necroptosis in alveolar epithelial cells in vivo.
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Ameliorates IAV-induced lung inflammation while leaving viral clearance and other functions of the immune response.
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Solubility: DMSO: 100 mg/mL (226.49 mM; Need ultrasonic)
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CAS No.: 2763602-16-8
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Research Area: Interleukin Related/IL-23 Receptor/Inflammation
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A selective and orally active IL-23 receptor antagonist with a Kd of 7.1 pM.
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Inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and potently inhibits IL-23-induced generation of IFNγ and IL-17A.
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Can be used for the study of immune-mediated inflammatory diseases driven by dysregulated IL-23 signaling.
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Solubility: DMSO: 100 mg/mL (52.68 mM; Need ultrasonic)
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MCE Peptides
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Structural
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Product Name
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Description
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Cyclo(CKLIIF) TFA
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A dual inhibitor for hypoxia inducible factor (HIF) 1 and 2.
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DPLG3
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A specific chymotryptic-like β5i subunits inhibitor (IC50=9.4 nM).
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MCE Natural Products
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Obesity is a disease and a risk factor for other diseases, such as heart disease, diabetes and cancer. Therefore, controlling obesity is of great significance to many diseases, among which natural products have great potential in controlling obesity.
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Product Name
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Description
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Puerarin
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Inhibits the dorsal motor nucleus of vagus (DMV)-vagus pathway, which in turn leads to reduced fat absorption.
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Hyperforin
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Triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
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Equisetin
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An anti-obesity agent through targeting 11β-HSD1.
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Saikosaponin A
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Improves obesity-related metabolic dysfunction by activating PPARγ.
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Soyasaponin Ab
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Exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ.
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MCE Compound Library
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Provide professional compound library, serving cancer, immunity, metabolism and other fields of research.
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Product Name
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Description
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Structurally Diverse Fragment Library
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Contains 2,300+ molecules with high structural diversity that meet ‘RO3’ criteria, which can be applied to fragment-based drug development.
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Drug Fragment Library
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Contains 1,000 drug fragments, all of which are derived from FDA-approved drug molecules. These fragments are correlated with good PK/PD properties. Besides, fragment-based screening can reserve enough chemical space for subsequent structural optimization.
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Vitamin Compound Library
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Contains 140+ vitamins and their derivatives, which can be used to build a platform for vitamin metabolism research, serving as a good tool to explore the metabolic pathways of vitamins within biological systems.
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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Contains 3,100+ compounds have clear or potential anti-NAFLD activity, serving as essential tools for investigating the pathogenesis of NAFLD and for drug development.
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Latest Publications Citing Use of MCE Products
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Nature.
2024 Aug;632(8027):1137-1144.
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Nature.
2024 Aug;632(8026):903-910.
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Nature.
2024 Aug;632(8026):930-937.
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Nature.
2024 Aug;632(8026):893-902.
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Cell.
2024 Sep 5;187(18):5064-5080.e14.
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Products are for research use only and are not intended for human use. We do not sell to patients.
We respect your privacy and do not share or sell your information to third parties.
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