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【Medchemexpress】New Bioactive Molecules for July 2024

  • 2024/07/05
  • サプライヤニュース

新着情報一覧へ

MedChemExpress - Master of Bioactive Molecules (Inhibitors. Screening Libraries. Proteins)
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
•  Over 100,000 bioactive molecules in stock
•  Target 10,000+ key proteins in 20+ signaling pathways
•  Quality reports (LC/MS, NMR and HPLC) for each product
•  Release more than 1,000 latest biochemicals per month
•  Data sheet with detailed biological information
•  High purity & competitive prices
•  Delivery within 24 hours

CAS No.: 2851885-95-3

ARV-393
 

Research Area: PROTAC/BCL6/Non-Hodgkin’s Lymphoma

ARV-393 structure
An orally active PROTAC that recruits BCL6 and the E3 ligase cereblon to rapidly degrade BCL6.
Shows DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines.
Used for the research of many types of non-Hodgkin's lymphoma.

Solubility: DMSO: 20.83 mg/mL (23.19 mM; ultrasonic and warming and heat to 60°C)

CAS No.: 313368-91-1

Lumateperone
 

Research Area: 5-HT Receptor/Dopamine Receptor/Neurological Diseases

Lumateperone structure
A 5-HT2A receptor antagonist (Ki of 0.54 nM), and a dopamine receptor modulator.
An orally atcive antipsychotic that can alleviate both schizophrenia and bipolar depression.

Solubility: DMSO: 125 mg/mL (317.66 mM; Need ultrasonic)

CAS No.: 870762-83-7

CYM-5478
 

Research Area: LPL Receptor/S1P2/Cancer

CYM-5478 structure
A selective sphingosine-1-phosphate receptor 2 (S1P2) agonist with an EC50 of 119 nM.
Protects neural-derived cell lines against Cisplatin toxicity.

Solubility: DMSO: 100 mg/mL (257.48 mM; Need ultrasonic)

MCE Apoptosis Analysis Kits
 
 
Apoptosis assays encompass chromatin condensation, in situ DNA fragment detection, assessment of mitochondrial membrane potential, as well as identification of cell surface markers like phosphatidylserine (PS).
MCE offers a range of high-quality apoptosis assay kits to support your scientific research endeavors
Cat. No Product Name Application
HY-K1072 Cell Apoptosis Analysis Kit (Hoechst staining) Chromatin Condensation
HY-K1092 YO-PRO-1/PI Apoptosis and Necrosis Detection Kit
HY-K0601 JC-1 Mitochondrial Membrane Potential Assay Kit Mitochondrial Membrane Potential
HY-K1073 Annexin V-FITC/PI Apoptosis Detection Kit Phosphatidylserine Exposure
HY-K1080 Annexin V-iFluor 488/PI Apoptosis Detection Kit
HY-K1093 VF 647A-Annexin V/PI Apoptosis Detection Kit
HY-K1078 One Step TUNEL Apoptosis Detection Kit (FITC) DNA Fragmentation (TUNEL Method)
HY-K1079 One Step TUNEL Apoptosis Detection Kit (Cyanine 3)
HY-K1091 TUNEL Apoptosis Detection Kit (Biotin)
HY-K1088 VF 488 Caspase 3 Assay Kit for Live Cells Caspase Detection
 
MCE Natural Products
 
 
Over 40 cyclic peptide drugs are currently in clinical use, and the vast majority of clinically approved cyclic peptides are derived from natural products, such as antimicrobials or human peptide hormones.
Product Name Description
Heterophyllin B An active cyclic peptide that can be used for the study of esophageal cancer.
Segetalin B A cyclopentapeptide with an estrogen-like activity.
Jasplakinolide A potent actin polymerization inducer with fungicidal and anti-cancer activities.
Pristinamycin IA A cycle-peptidic macrolactone antibiotic, and a substrate of P-glycoprotein and inhibits its function.
Destruxin B A cyclic peptide with insecticidal and anticancer activities that induces apoptosis in tumor cells.
 
MCE Compound Library
 
 
Provides a professional compound library to serve research in multiple fields including cancer, immunity, and metabolism.
Product Name Description
Anti-Gastric Cancer Compound Library Contains 600+ anti-gastric cancer compounds that can be used for the gastric cancer research.
Anti-Fibrosis Compound Library Contains 800+ anti-fibrosis compounds that can be used for fibrosis-related diseases.
Neurotransmitter Compound Library Contains 50+ neurotransmitters that can be used in the study of neurological diseases.
Latest Publications Citing Use of MCE Products
Covers of Recent Publications Nat Med.
2024 Jun;30(6):1696-1710.
Nature.
2024 Jun;630(8015):237-246.
Cell.
2024 Jun 6;187(12):2935-2951.e19.
Cell Signaling Pathway
MCE USA
Tel: 609-228-6898 E-mail: sales@MedChemExpress.com
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
MCE Europe
Tel: +4686500910 E-mail: eu.sales@MedChemExpress.com
Address: Bergkällavägen 37C 192 79 Sollentuna SWEDEN
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Products are for research use only and are not intended for human use. We do not sell to patients.

Medchemexpress(メドケムエクスプレス)社について

設立
2009年
本社所在地
アメリカ
URL
http://www.medchemexpress.com/

MedChemExpress(MCE)は、新規のライフサイエンス試薬、薬理活性化合物、APIなど高品質の研究化学物質および生化学物質を幅広く提供しております。MCE のテクニカルサポートチームは経験が豊富であり、ライフサイエンス業界においては長年の経験を積んでおります。

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