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- サプライヤー
- AcroBioSystems
- カタログNo.
- ZE5-V5221
- 製品名称
- Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) Envelope Glycoprotein (GP) Protein, His Tag
- タンパク質名
- Glycoprotein/GP (EBOV)
- Species
- Ebolavirus
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) GP, His Tag, containing GP1 and GP2, is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 67.2 kDa. The reducing (R) protein migrates as 21-23 kDa (GP2-delta) and 110-120 kDa (GP1) when calibrated against Star Ribbon Pre-stained Protein Marker in SDS-PAGE. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 85% |
| Description | EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/glycoprotein-gp-ebov-ebolavirus-ze5-v5221 |
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