ナミキ商事株式会社 医薬品及び創薬化学品の専門商社

医薬品及び創薬化学品の専門商社

検索検索

バイオ製品Bio Products

リコンビナントタンパク質

ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
ZE5-V5221
製品名称
Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) Envelope Glycoprotein (GP) Protein, His Tag
タンパク質名
Glycoprotein / GP (virus)
Species
Ebolavirus
HOST
HEK293
1mg: 554400円
お問い合わせ
100ug: 81200円
お問い合わせ

Overview

Synonyms -
Characteristics Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) GP, His Tag, containing GP1 and GP2, is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 67.2 kDa. The reducing (R) protein migrates as 21-23 kDa (GP2-delta) and 110-120 kDa (GP1) in SDS-PAGE.
Endotoxin Level 1.0 EU per μg
Purity 85%
Description EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
Reference -
URL https://www.acrobiosystems.com/P1701-Ebolavirus-EBOV-%28subtype-Zaire-strain-Kikwit-95%29-Envelope-Glycoprotein-%28GP%29-Protein-His-Tag.html

お問い合わせリスト(-)

お問い合わせフォーム