Human WEE1 Protein, His Tag (active enzyme) [WE1-H5543]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 51.1 kDa. The protein migrates as 8 kDa,30-33 kDa and 55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	80%
Description	WEE1?? is a ??serine/threonine protein kinase?? that acts as a ??critical regulator of the cell cycle??, particularly at the ??G?/M checkpoint??. It inhibits cell cycle progression by phosphorylating and inactivating ??CDK1?? (Cyclin-Dependent Kinase 1) at Tyr15, thereby preventing premature entry into mitosis and allowing time for DNA repair.Originally identified in fission yeast, WEE1 is highly conserved in mammals and plays a key role in maintaining genomic stability. Dysregulation of WEE1 is linked to ??cancer progression??, as its overexpression in tumors (e.g., ovarian, breast, pancreatic cancers) supports cancer cell survival by enabling DNA damage tolerance. This dependency makes WEE1 a ??promising therapeutic target??, especially in p53-mutant cancers where inhibiting WEE1 induces synthetic lethality by forcing cells with unrepaired DNA into catastrophic mitosis.
Reference	-
URL	N/A

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