ACROBiosystems社 プロダクトリスト：Recombinant Protein
- ActiveMax Recombinant Mouse VEGF164 (HPLC-verified)
|Characteristics||This protein carries no "tag". The protein has a calculated MW of 19.3 kDa. The protein migrates as 23-25 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||Vascular endothelial growth factor A (VEGFA) is also known as Vascular permeability factor (VPF). VEGFA belongs to the PDGF/VEGF growth factor family. VEGFA is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. VEGFA is produced by a group of three major isoforms as a result of alternative splicing and if any three isoforms are produced (VEGFA120, VEGFA164, and VEGFA188) then this will not result in vessel defects and death of the full VEGFA knockout in mice.|
|Reference||(1) Shin S.-Y., et al., 2005, Yonsei Med. J. 46:679-686.
(2) Breier G., et al., 1992, Development 114:521-532.