Human USP1 & UAF1 Protein, GST Tag&Strep II Tag [US1-H85W3]

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Synonyms	-
Characteristics	Human USP1 & UAF1 Protein, GST Tag&Strep II Tag, produced by co-expression of USP1 and UAF1, has a calculated MW of 114.1 kDa (USP1) and 77.8 kDa (UAF1). Subunit USP1 is fused with a GST tag at the N-terminus and subunit UAF1 is fused with Strep II-tag at the C-terminus. The protein migrates as 80-95 kDa and 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	95%
Description	USP1 (ubiquitin?specific protease?1) is a deubiquitinating enzyme crucial for DNA damage repair, cell cycle regulation, and protein homeostasis. Its catalytic efficiency is markedly enhanced by UAF1 (USP1?associated factor?1), a cofactor that stabilizes USP1 and directs it to nuclear substrates. Together, the USP1?UAF1 complex removes ubiquitin from key proteins such as PCNA and FANCD2, maintaining genomic stability and influencing cancer development, making it a potential therapeutic target in oncology.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/usp1-uaf1-human-us1-h85w3

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