Human Tyk2 Protein, His Tag (active enzyme) [TY2-H5547]

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 38.5 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	N/A
Description	Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
Reference	-
URL	https://www.acrobiosystems.com/P7380-Human-Tyk2-Protein-His-Tag-%28active-enzyme%29.html

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