Human Transferrin R2 alpha Protein, Fc Tag [TRA-H5263]

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Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 102.8 kDa. The protein migrates as 120-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Transferrin R2 alpha, also known as TfR2α, is a type II transmembrane protein localized to the cell membrane and is primarily expressed in hepatocytes and erythroid precursors. Its functions include the uptake of iron-bound transferrin, acting as an iron-level sensor to regulate hepcidin for maintaining systemic iron homeostasis, and negatively regulating erythropoiesis. This protein is closely associated with diseases such as type 3 hereditary hemochromatosis, anemia, and β-thalassemia.
Reference	4708
URL	https://www.acrobiosystems.com/products/protein/transferrin-r2-alpha-human-tra-h5263

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