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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
TR2-H82E6
製品名称
Biotinylated Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avitag?,His Tag (MALS verified)
タンパク質名
TRAIL R2
Species
Human
HOST
HEK293
25ug: 98000円
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200ug: 425600円
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Overview

Synonyms -
Characteristics This protein carries an Avi tag (Avitag?) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 16.9 kDa. The protein migrates as 22 kDa and 24 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level 1.0 EU per μg
Purity 90%
Description Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
Reference -
URL https://www.acrobiosystems.com/P2382-Biotinylated-Human-TRAIL-R2--DR5--TNFRSF10B-Protein-Avitag%E2%84%A2His-Tag-%28MALS-verified%29.html

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