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- サプライヤー
- AcroBioSystems
- カタログNo.
- TR2-H5258
- 製品名称
- Human TREM2 (19-157) Protein, Fc Tag
- タンパク質名
- TREM2
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a pivotal cell-surface receptor primarily found on microglia in the brain and macrophages in peripheral tissues. Acting as a lipid and amyloid-beta sensor, it signals through the adapter protein DAP12 to regulate immune responses, cell survival, and phagocytosis. In neurobiology, TREM2 is a major focus because its dysfunction is strongly linked to Alzheimer’s disease progression and impaired clearance of neurotoxic plaques. |
| Reference | 4677 |
| URL | https://www.acrobiosystems.com/products/protein/trem2-human-tr2-h5258 |
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