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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-06983
- 製品名称
- IFN gamma Protein, Human, Recombinant (E. coli)
- タンパク質名
- IFN gamma
- Species
- Human
- HOST
- E. coli
- 20μg: -
- お問い合わせ
Overview
| Synonyms | Interferon Gamma, IFN γ, IFN gamma, IFG, IFI, Interferon γ |
|---|---|
| Characteristics | Measured in anti-viral assays using WISH cells infected with vesicular stomatitisvirus (VSV). The ED50?for this effect is 8-80 pg/mL |
| Endotoxin Level | < 5 EU/mg of the protein. |
| Purity | SDS-PAGE: 96.7%; SEC-HPLC: 96.9% |
| Description | IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and tumor control. Aberrant IFN gamma expression is associated with some autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity. |
| Reference | Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.,Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.,Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.,Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.,Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.,Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36. |
| URL | https://www.targetmol.com/recombinant-protein/recombinant_human_ifn_gamma_protein |
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