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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-06981
- 製品名称
- IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
- タンパク質名
- IL-1 alpha/IL-1A
- Species
- Human
- HOST
- E. coli
- 20μg: -
- お問い合わせ
Overview
| Synonyms | interleukin 1 α, IL1, IL-1F1, IL1-α, IL-1A, IL1F1, IL-1 α/IL1A, IL1-ALPHA, interleukin 1 alpha |
|---|---|
| Characteristics | Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50?for this effect is typically 0.5-3 ng/mL. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 97.50% |
| Description | IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. |
| Reference | Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.,March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.,Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.,Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93. |
| URL | https://www.targetmol.com/recombinant-protein/recombinant_human_il_1_alpha_il1a_protein |
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