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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-05717
- 製品名称
- Integrin alpha V beta 8 Protein, Human, Recombinant (His)
- タンパク質名
- Integrin alpha V beta 8
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | Integrin alpha V β8, Integrin α V β 8 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 97.1%; SEC-HPLC: 96.8% |
| Description | Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/integrin_alpha_v_beta_8_protein_human_recombinant_his_tag_hplc_verified |
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