4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc) [TMPY-05376]

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Synonyms	4-1BB, CDw137, CD137, ILA, tumor necrosis factor receptor superfamily, member 9
Characteristics	Measured by its binding ability in a functional ELISA. Immobilized TNFRSF9-Fc at 10 μg/ml(100 μl/well) can bind TNFSF9/Biotin , The EC50 of TNFSF9/Biotin is 20-60 ng/mL.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 95.6%; SEC-HPLC: 97.7%
Description	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44 kDa and the accession number is Q07011.
Reference	Sica G,et al.(1999) Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. Arch Immunol Ther Exp (Warsz). 47(5): 275-9.,Wang Q,et al.(2008) Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J. 49(2): 192-200.,Thum E,et al.(2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.,Nam KO,et al.(2005)?The therapeutic potential of 4-1BB (CD137) in cancer.?Curr Cancer Drug Targets. 5(5): 357-63.,Melero I,et al.(2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.
URL	https://www.targetmol.com/recombinant-protein/4_1bb_cd137_protein_human_recombinant_ecd_hfc_tag_hplc_verified

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