PCSK9 Protein, Human, Recombinant (D374Y, His) [TMPY-04966]

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Synonyms	LDLCQ1, NARC-1, PC9, NARC1, HCHOLA3, proprotein convertase subtilisin/kexin type 9, FH3
Characteristics	1.Measured by its binding ability in a functional ELISA. Immobilized Human LDLR mFc at 2 μg/ml (100 μl/well) can bind Human PCSK9(D374Y) His, the EC50 of PCSK9（D374Y) His is 1-20 ng/mL. 2.Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag on ProA Biosensor, can bind Recombinant Human PCSK9 (D374Y) Protein, His Tag with an affinity constant of 2.57nM as determined in BLI assay (Routinely tested).
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 97.7%; SEC-HPLC: 92.9%
Description	PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
Reference	Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.,Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498,Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.,Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.,Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
URL	https://www.targetmol.com/recombinant-protein/pcsk9_protein_human_recombinant_d374y_his_tag_hplc_verified

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