CD47 Protein, Human, Recombinant (aa 1-139, His) [TMPY-04935]

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Synonyms	IAP, OA3, MER6, CD47 molecule
Characteristics	1. Measured by its binding ability in a functional ELISA. Immobilized Human SIRP alpha hFc at 2 μg/mL (100 μL/well) can bind Human CD47 His, the EC50 of Human CD47 His is 5.0-25.0 ng/mL.<br> 2. Captured Ligufalimab (IgG4) on proA Chip?can?bind CD47 with?an?affinity?constant of 10.82 nM as determined in a SPR assay (Routinely tested).<br> 3. Loaded Hu5F9-G4 (IgG4) on ProA Biosensor, can bind human CD47 protein, His Tag with an affinity constant of 3.02 nM as determined in BLI assay (Routinely tested).
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 98.4%; SEC-HPLC: 97.6%
Description	CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3.
Reference	Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.,Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.,Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.
URL	https://www.targetmol.com/recombinant-protein/cd47_protein_human_recombinant_ecd_his_tag_hplc_verified

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