DLL4 Protein, Human, Recombinant [TMPY-04803]

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Synonyms	δ-like 4 (Drosophila), delta-like 4 (Drosophila), Delta-like 4, hdelta2, δ-like 4, hδ2
Characteristics	Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is typically 4-20 ?g/mL in the presence of 500 ng/mL recombinant human BMP2.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	95.90%
Description	DLL4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55 kDa and the accession number is Q9NR61.
Reference	Histopathology. 54(5): 598-606.Li JL,et al.(2010) Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. Future Oncol. 6(7): 1099-103.,Sainson RC,et al.(2007) Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med. 13(9): 389-95.,Yan M,et al.(2007) Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 13(24): 7243-6.,Martinez JC,et al.(2009) Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.
URL	https://www.targetmol.com/recombinant-protein/dll4_protein_human_recombinant_hplc_verified

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