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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-04544
- 製品名称
- MEK2 Protein, Human, Recombinant (GST)
- タンパク質名
- MEK2
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | mitogen-activated protein kinase kinase 2, FLJ26075, MKK2, CFC4, PRKMK2, MEK2, MAPKK2 |
|---|---|
| Characteristics | No Kinase Activity |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 91.30% |
| Description | Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion and growth factor signaling. MAP2K1 / MEK1 is a crucial modulator of Mek and Erk signaling and have potential implications for the role of MEK1 and MEK2 in tumorigenesis. MAP2K2 / MEK2 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. It also activates the ERK1 and ERK2 MAP kinases. Defects in MAP2K2 are a cause of Cardiofaciocutaneous Syndrome (CFC Syndrome) which is characterized by a distinctive facial appearance, heart defects, and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects, and hypertrophic cardiomyopathy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Reference | Narumi,Y. et al., 2007, Am J Med Genet A. 143A?(8):799-807.,MacDonald,T.J. et al., 2001, Nat Genet. 29?(2):143-52.,Daub H., et al., 2008, Mol. Cell 31:438-448.,Catalanotti,F. et al., 2009, Nat Struct Mol Biol. 16?(3):294-303.,Mittal R., et al., 2006, Proc. Natl. Acad. Sci. USA. 103:18574-9. |
| URL | https://www.targetmol.com/recombinant-protein/mek2_protein_human_recombinant_gst_tag_ |
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