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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-04456
- 製品名称
- PKC nu Protein, Human, Recombinant (GST)
- タンパク質名
- PKC nu
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | PRKCN, nPKC-NU, PKC-NU, PKD3, EPK2, protein kinase D3 |
|---|---|
| Characteristics | Kinase activity untested |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | ? 80 % as determined by SDS-PAGE |
| Description | Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. They also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. PRKD3 / PRKCN converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. It is involved in resistance to oxidative stress. PRKD3 / PRKCN is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. PRKD3 / PRKCN can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. PRKD3 / PRKCN can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members. |
| Reference | Mayne M, et al., 2000, J. Immunol.?164?(12): 6538-42.Ali A, et al., 2002, Chem. Rev.?101?(8): 2527-40.,HAyashi A, et al., 1999, Biochim Biophys Acta?1450?(1): 99-106.,Schultz SJ, et al.,1994, Cell Growth Differ.?4?(10): 821-30. |
| URL | https://www.targetmol.com/recombinant-protein/pkc_nu_protein_human_recombinant_gst_tag_ |
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