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タンパク質カタログ
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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-04375
- 製品名称
- Casein Kinase 1 alpha Protein, Human, Recombinant (GST)
- タンパク質名
- Casein Kinase 1 alpha
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | CKIa, casein kinase 1, alpha 1, casein kinase 1, α1, HEL-S-77p, CK1a, Casein Kinase 1 α, PRO2975, CK1, HLCDGP1 |
|---|---|
| Characteristics | The specific activity was determined to be 30 nmol/min/mg using casein as substrate. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | > 85 % as determined by SDS-PAGE |
| Description | Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis. |
| Reference | Wang,Z. et al., 2010, Med Sci Monit.16?(8):CR357-64.,Dubois, T et al.,2001,?J. Biol. Chem.(United States)?276?(22): 18757-64.,Zhang, Yi et al.,?2002, J. Biol. Chem.?277(20): 17706-12.,Dubois, et al.,2002, FEBS Lett.?(Netherlands)?517?(1-3): 167-71. |
| URL | https://www.targetmol.com/recombinant-protein/casein_kinase_1_alpha_protein_human_recombinant_gst_tag_ |
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