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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-04348
- 製品名称
- CTLA-4 Protein, Human, Recombinant (His)
- タンパク質名
- CTLA-4
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | ALPS5, CD152, GRD4, cytotoxic T-lymphocyte-associated protein 4, GSE, IDDM12, CELIAC3, CTLA-4, CD |
|---|---|
| Characteristics | 1. Immobilized Recombinant Human CD86/B7-2 Protein (Fc Tag) at 2 μg/mL (100 μL/well) can bind Recombinant Human CTLA-4 Protein (His Tag) , the EC50 is 2.6-8 ng/mL.<br> 2. Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.05-0.3 μg/mL when stimulated with 1 μg/mL Recombinant Human B7?1/CD80.<br> 3. Captured Ipilimumab on proA Chip can bind CTLA-4 with an affinity?constant of 20.03 nM as determined in a SPR assay (Routinely tested).<br> 4. Loaded Ipilimumab on ProA Biosensor, can bind CTLA-4 Protein, Human, Recombinant, His Tag with an affinity constant of 5.15 nM as determined in BLI assay (Routinely tested). |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 99.7%; SEC-HPLC: 98.3% |
| Description | CTLA-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1. |
| Reference | Holmberg D,et al.(2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.,Chin LT,et al.(2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.,Slavik JM,et al.(1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24. |
| URL | https://www.targetmol.com/recombinant-protein/ctla_4_protein_human_recombinant_his_tag_hplc_verified |
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