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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-04343
- 製品名称
- PD-L1 Protein, Human, Recombinant (His)
- タンパク質名
- PD-L1
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | PDL1, B7-H, B7H1, PDCD1LG1, CD274 molecule, PD-L1, PDCD1L1, B7-H1 |
|---|---|
| Characteristics | 1. Immobilized Anti-PDL1(GEN)-IgG1 Antibody (Atezolizumab) at 2 μg/mL (100 μL/well) can bind Recombinant Human PD-L1/B7-H1/CD274 Protein (His Tag), the EC50 is 0.7-2.1 ng/mL.<br> 2. Captured Anti-PD-L1 Mab (Human IgG1) on?proA Chip?can?bind PD-L1 with?an affinity constant of 1.381 nM as determined in a SPR assay (QC?tested). |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 98.6%; SEC-HPLC: 99.2% |
| Description | PD-L1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is Q9NZQ7-1. |
| Reference | Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.,Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.,Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.,Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.,Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7. |
| URL | https://www.targetmol.com/recombinant-protein/pd_l1_protein_human_recombinant_ecd_his_tag_hplc_verified |
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