RANK/TNFRSF11A Protein, Human, Recombinant (hFc) [TMPY-04142]

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Synonyms	FEO, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNFRSF11A, CD265, ODFR, RANK, PDB2, OSTS, LOH18CR1, OPTB7, OFE
Characteristics	Measured by its ability to inhibit TRANCE-induced osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 3-16ng/mL in the presence of 5 ng/mL of TRANCE.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	95.40%
Description	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
Reference	Darnay B G, et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 274(12):7724-31.,Galibert L, et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 273(51):34120-7.,Darnay B G, et al. (1998) Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 273(32):20551-5.
URL	https://www.targetmol.com/recombinant-protein/rank_tnfrsf11a_protein_human_recombinant_hfc_tag_

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