DNase I Protein, Human, Recombinant (His) [TMPY-03855]

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Synonyms	DRNI, DNL1, deoxyribonuclease I
Characteristics	One unit is defined as the amount of DNase I that degrades DNA and causes an increase in absorbance at 260 nm of 0.001/minute at 25°C , pH 5.0; The specific activity is >5000 unit/mg.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	92.50%
Description	DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.
Reference	Yasutomo K. et al., 2001, Nat Genet. 28 (4): 313-4.,HAkkim A. et al., 2010, Proc Natl Acad Sci. 107 (21): 9813-8.,Shak S. et al., 1991, Proc Natl Acad Sci. 87 (23): 9188-92.
URL	https://www.targetmol.com/recombinant-protein/dnase_i_protein_human_recombinant_his_tag_

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