Vaccinia Virus B18R/B19R Protein (His) [TMPY-03758]

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Synonyms	-
Characteristics	Measured by its ability to neutralize B18R-mediated inhibition of WISH cell pathology, IFNA2 can bind to B18R and counteract its inhibitory effect. The neutralization rate, reflecting the activity of B18R, is calculated by measuring cell viability using the MTT assay. The ED50 for this effect is 0.16-1.2 ng/mL.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	97.40%
Description	B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to uninfected and infected cells. It presents at the cell surface and protects cells from the antiviral state induced by IFN-alpha and IFN-beta. Binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.
Reference	Colamonici OR. et al., 1995, J Biol Chem. 270 (27): 15974-8.,Goebel SJ. et al., 2010, J Cell Biol. 190 (4): 533-9.,Goebel SJ. et al., 1990, Virology 179: 247-66.,I Vancov. et al., 1998, J Gen Virol July. 79 (7): 1647-9.
URL	https://www.targetmol.com/recombinant-protein/vaccinia_virus_b18r_b19r_protein_his_tag_

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