PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His) [TMPY-03670]

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Synonyms	CD274 molecule
Characteristics	Measured by its ability to bind ?Cynomolgus PD1-Fc ?in a functional ELISA.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 95.8%; SEC-HPLC: 93.1%
Description	PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52 kDa and the accession number is XP_015292694.1&XP_014973151.1.
Reference	Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.,Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.,Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.,Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.,Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
URL	https://www.targetmol.com/recombinant-protein/cynomolgus_rhesus_pd_l1_b7_h1_cd274_protein_his_tag_

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