RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) [TMPY-03527]

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Synonyms	CD254, tumor necrosis factor (ligand) superfamily, member 11, ODF, RANKL, sOdf, hRANKL2, TNFSF11, OPGL, TRANCE, OPTB2
Characteristics	1. Measured by its binding ability in a functional ELISA. Immobilized Human Osteoprotegerin His at 2 μg/ml (100 μl/well) can bind Human RANKL rFc, the EC50 of Human RANKL rFc is 3.0-15.0 ng/mL. 2. The bioactivity of hRANKL was determined by measuring the ability of hRANKL to induce TRAP activity in Raw 264.7 cells. The ED50 for this effect is 1.5-7.5ng/mL.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	95.60%
Description	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
Reference	Nakashima T,et al.(2003) RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3): 280-7.,Takayanagi H,et al.(2002) Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res. 4 Suppl 3: S227-32.,Schwarz EM,et al.(2007) Clinical development of anti-RANKL therapy. Arthritis Res Ther. 9 Suppl 1: S7.,Leibbrandt A,et al.(2008) RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143: 123-50.
URL	https://www.targetmol.com/recombinant-protein/rankl_protein_human_recombinant_rfc_tag_

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