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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-03425
- 製品名称
- Fetal-tau Protein, Human, Recombinant (His)
- タンパク質名
- Tau
- Species
- Human
- HOST
- E. coli
- 50μg: -
- お問い合わせ
Overview
| Synonyms | PPND, FTDP-17, MTBT1, DDPAC, MAPTL, MTBT2, microtubule-associated protein tau, PPP1R103, MAPT, MSTD, TAU |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 89.20% |
| Description | MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs. |
| Reference | Harada A, et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369(6480):488-91.,Weingarten MD, et al. (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci. 72(5):1858-62.,Goedert M, et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 3(4): 519-26. |
| URL | https://www.targetmol.com/recombinant-protein/tau_protein_human_recombinant_his_tag_ |
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