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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-03407
- 製品名称
- NQO1 Protein, Human, Recombinant (His)
- タンパク質名
- NQO1
- Species
- Human
- HOST
- E. coli
- 50μg: -
- お問い合わせ
Overview
| Synonyms | NAD(P)H dehydrogenase, quinone 1, NMORI, DIA4, QR1, NMOR1, DTD, DHQU |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | Please contact us for more information. |
| Purity | SDS-PAGE: 96%; SEC-HPLC: 99.7% |
| Description | NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests the feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein. |
| Reference | Adesnik M. et al., 1988, J Biol Chem. 263 (27): 13572-8.,Ross David. et al., 2002, J Biol Chem. 277 (16): 14060-7.,Cabello CM. et al., 2010, Free Radic Res. 45 (3): 276-92. |
| URL | https://www.targetmol.com/recombinant-protein/nqo1_protein_human_recombinant_his_tag_ |
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