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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02929
- 製品名称
- ENTPD2 Protein, Human, Recombinant (aa 29-460, His)
- タンパク質名
- ENTPD2
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | ectonucleoside triphosphate diphosphohydrolase 2, NTPDase-2, RP11-229P13.11-001, CD39L1 |
|---|---|
| Characteristics | Measured by its ability to hydrolyze the 5’phosphate groups from the substrate adenosine 5’triphosphate(ATP). The specific activity is > 5,000 pmoles/min/μg. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 94.90% |
| Description | NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants. |
| Reference | Harden TK, et al. (2005) Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2. Mol Pharmacol. 67(1): 114-22.,Dranoff JA, et al. (2005) Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. J Investig Med. 52(7):475-82.,Mukasa T, et al. (2005) Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8). Biochemistry. 44(33):11160-70.,Jhandier MN, et al.. (2005) Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. J Biol Chem. 280(24):22986-92. |
| URL | https://www.targetmol.com/recombinant-protein/entpd2_protein_human_recombinant_aa_29_460_his_tag_ |
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