GDNF Protein, Rat, Recombinant (His) [TMPY-02911]

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Synonyms	glial cell derived neurotrophic factor
Characteristics	1. Measured in a cell proliferation assay using SH?SY5Y human neuroblastoma cells. The ED50 for this effect is typically 10-50 ng/mL in the presence of Recombinant Rat GFR alpha?1/GDNF R alpha?1 His Chimera. 2. Immobilized rat His-GDNF (78-211) at 10 μg/ml (100 μl/well) can bind rat GFRA1-Fc , The EC50 of rat GFRA1-Fc is 20-46.6 ng/ml.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	> 95 % as determined by SDS-PAGE
Description	GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is Q07731-1.
Reference	Oppenheim RW,et al. (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature. 373 (6512): 344-6.,Genomics. 28 (3): 605-7.Carnicella S,et al. (2008) GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci . 105 (23): 8114-9.,Tomac A,et al. (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373 (6512): 335-9.,Schindelhauer D,et al. (1996) The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1.
URL	https://www.targetmol.com/recombinant-protein/gdnf_protein_rat_recombinant_his_tag_

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