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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02907
- 製品名称
- FGF-19 Protein, Human, Recombinant
- タンパク質名
- FGF-19
- Species
- Human
- HOST
- E. coli
- 50μg: -
- お問い合わせ
Overview
| Synonyms | fibroblast growth factor 19, FGF19 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 10 EU/mg of the protein. |
| Purity | SDS-PAGE: 97.4%; SEC-HPLC: 99.5% |
| Description | FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It also stimulates glucose uptake in adipocytes. |
| Reference | Goetz R,et al. (2007) Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 27(9):3417-28.,Harmer NJ,et al. (2004) The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry. 43(3):629-40.,Tamimi Y,et al. (2006) FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. Hum Mol Genet. 15(21):3229-40. |
| URL | https://www.targetmol.com/recombinant-protein/fgf19_protein_human_recombinant_hplc_verified |
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