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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02801
- 製品名称
- PHGDH Protein, Human, Recombinant (His)
- タンパク質名
- PHGDH
- Species
- Human
- HOST
- E. coli
- 100μg: -
- お問い合わせ
Overview
| Synonyms | phosphoglycerate dehydrogenase, HEL-S-113, 3PGDH, NLS1, PHGDHD, 3-PGDH, PGD, PDG, SERA, PGAD, PGDH, NLS |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 96% |
| Description | PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PHGDH catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. Overexpression of PHGDH may cause certain breast cancers. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency which is characterized by congenital microcephaly, psychomotor retardation, and seizures. |
| Reference | Possemato R,et al. (2011) Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476 (7360): 346-50.,Pind S,et al. (2002) V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. J Biol Chem. 277 (9): 7136-43.,Du H,et al. (2010) 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction. 139 (1): 237-45. |
| URL | https://www.targetmol.com/recombinant-protein/phgdh_protein_human_recombinant_his_tag_ |
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