PHGDH Protein, Human, Recombinant (His) [TMPY-02801]

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Synonyms	phosphoglycerate dehydrogenase, HEL-S-113, 3PGDH, NLS1, PHGDHD, 3-PGDH, PGD, PDG, SERA, PGAD, PGDH, NLS
Characteristics	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Endotoxin Level	Please contact us for more information.
Purity	96%
Description	PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PHGDH catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. Overexpression of PHGDH may cause certain breast cancers. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency which is characterized by congenital microcephaly, psychomotor retardation, and seizures.
Reference	5448
URL	https://www.targetmol.com/recombinant-protein/phgdh_protein_human_recombinant_his_tag_

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