GDNF Protein, Human, Recombinant (HEK293) [TMPY-02792]

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Synonyms	HSCR3, ATF2, HFB1-GDNF, ATF1, glial cell derived neurotrophic factor
Characteristics	1. Measured in a cell proliferation assay using SH?SY5Y human neuroblastoma cells. The ED50 for this effect is typically 3-20 ng/mL in the presence of Recombinant Human GFR alpha?1/GDNF R alpha?1 His Chimera. 2. Immobilized Recombinant Human GDNF Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human GFRA1 / GFRα1 / GDNFRA Protein (His Tag) , the EC50 is 15-48 ng/mL.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	96.80%
Description	GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
Reference	Genomics. 28 (3): 605-7.Carnicella S,et al. (2008) GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci . 105 (23): 8114-9.,Tomac A,et al. (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373 (6512): 335-9.,Schindelhauer D,et al. (1996) The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1.,Oppenheim RW,et al. (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature. 373 (6512): 344-6.
URL	https://www.targetmol.com/recombinant-protein/gdnf_protein_human_recombinant

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