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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02700
- 製品名称
- BCL2 Protein, Human, Recombinant (His)
- タンパク質名
- BCL2
- Species
- Human
- HOST
- E. coli
- 100μg: -
- お問い合わせ
Overview
| Synonyms | Bcl-2, PPP1R50, B-cell CLL/lymphoma 2 |
|---|---|
| Characteristics | Measured by its binding ability in a functional ELISA. Immobilized human BCL2-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse BCL2L1-His , The EC50 of biotinylated mouse BCL2L1-His is 0.07-0.15 μg/ml. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 96% |
| Description | BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes. It is expressed in a variety of tissues. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Reference | Otake Y,et al.(2007) Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of Bcl-2 / Bcl-2 mRNA. Blood. 109(7):3069-75.,Tsujimoto Y,et al.(1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science. 226(4678):1097-99.,Cleary ML,et al.(1986) Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell. 47(1):19-28. |
| URL | https://www.targetmol.com/recombinant-protein/bcl_2_protein_human_recombinant_his_tag_ |
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