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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02603
- 製品名称
- STAT6 Protein, Human, Recombinant (His)
- タンパク質名
- STAT6
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | STAT6C, IL-4-STAT, STAT6B, signal transducer and activator of transcription 6, interleukin-4 induced, D12S1644 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 91.10% |
| Description | Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB. |
| Reference | Yang J,et al. (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 21 (18): 4950-8.,Litterst CM,et al. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 276 (49): 45713-21.,Stutz AM,et al. (1999) Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 163 (8): 4383-91. |
| URL | https://www.targetmol.com/recombinant-protein/stat6_protein_human_recombinant_his_tag_ |
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