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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02550
- 製品名称
- Eotaxin/CCL11 Protein, Human, Recombinant (His)
- タンパク質名
- Eotaxin/CCL11
- Species
- Human
- HOST
- E. coli
- 50μg: -
- お問い合わせ
Overview
| Synonyms | SCYA11, chemokine (C-C motif) ligand 11 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 97.70% |
| Description | CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. They share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. CCL11 is implicated in allergic responses through selectively recruiting eosinophils by inducing their chemotaxis. The effects of CCL11 are mediated by its binding to chemokine receptor. Increased CCL11 levels in blood plasma are associated with aging in mice. |
| Reference | Biber K,et al.(2003) Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Journal of Leukocyte Biology. 74 (2): 243-51.,Laing KJ,et al.(2004) Chemokines. Developmental and comparative immunology. 28 (5): 443-60.,Hori T,et al.(2008) CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood. 111 (8): 4403-12.,Cocchi F,et al.(1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+T cells. Science. 270 (5243): 1811?5. |
| URL | https://www.targetmol.com/recombinant-protein/eotaxin_ccl11_protein_human_recombinant_his_tag_ |
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