RGMA Protein, Human, Recombinant (His) [TMPY-02525]

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Synonyms	repulsive guidance molecule family member a, RGM
Characteristics	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 87.1%; SEC-HPLC: 90.6%
Description	RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. This protein may also function as a tumor suppressor in some cancers.
Reference	Matsunaga E,et al.(2004) RGM and its receptor neogenin regulate neuronal survival. Nature Cell Biology. 6: 749-55.,Monnier PP,et al.(2002) RGM is a repulsive guidance molecule for retinal axons. Nature. 419: 392-5.,Severyn CJ,et al.(2009). Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J. 422 (3): 393-403.
URL	https://www.targetmol.com/recombinant-protein/rgma_protein_human_recombinant_his_tag_hplc_verified

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