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タンパク質カタログ
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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02483
- 製品名称
- ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
- タンパク質名
- ATP citrate lyase/ACLY
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 50μg: -
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Overview
| Synonyms | ATP citrate lyase, CLATP, ATPCL, ACL |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 96% |
| Description | ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation. |
| Reference | Ki SW,et al. (2000) Radicicol binds and inhibits mammalian ATP citrate lyase. J Biol Chem. 275 (50) : 39231-6.,Kim W,et al. (2006) Both subunits of ATP-citrate lyase from Chlorobium tepidum contribute to catalytic activity. J Bacteriol. 188 (18) : 6544-52.,Schneider K,et al. (2000) Biosynthesis of the prosthetic group of citrate lyase. Biochemistry. 39 (31) : 9438-50. |
| URL | https://www.targetmol.com/recombinant-protein/atp_citrate_lyase_acly_protein_human_recombinant_his_tag_ |
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