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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02245
- 製品名称
- SNAP-25 Protein, Human, Recombinant (His)
- タンパク質名
- SNAP-25
- Species
- Human
- HOST
- E. coli
- 100μg: -
- お問い合わせ
Overview
| Synonyms | SEC9, SNAP, synaptosomal-associated protein, 25kDa, SNAP-25, bA416N4.2, RIC-4, dJ1068F16.2, RIC4 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 91.10% |
| Description | Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP25 / SUP is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP25 / SUP is involved in the molecular regulation of neurotransmitter release. It may play an important role in the synaptic function of specific neuronal systems. SNAP25 / SUP associates with proteins involved in vesicle docking and membrane fusion. SNAP25 / SUP regulates plasma membrane recycling through its interaction with CENPF. SNAP25 / SUP inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP25 / SUP decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses. |
| Reference | Huang Q., et al., 2008, FEBS Lett. 582:1431-1436.,Chen X., et al., 2002, Neuron 33:397-409.,Hodel A , et al.,1998, Int. J. Biochem. Cell Biol.?30?(10): 1069-73.,Chapman ER et al.,2002, Nat. Rev. Mol. Cell Biol.?3(7): 498-508.,Sudhof TC, et al.,2002, Nat Rev Neurosci?3?(8): 641-653. |
| URL | https://www.targetmol.com/recombinant-protein/snap_25_protein_human_recombinant_his_tag_ |
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