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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02204
- 製品名称
- LBP Protein, Human, Recombinant (His)
- タンパク質名
- LBP
- Species
- Human
- HOST
- HEK293 Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | BPIFD2, lipopolysaccharide binding protein |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 98.40% |
| Description | Lipopolysaccharide binding protein ( LBP ) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides ( LPSs ). LBP binds directly to the outer membrane of Gram-negative bacteria and purified aggregates of extracted endotoxin and catalyzes the delivery of endotoxin to the membrane ( mCD14, GPI-Linked ) and soluble ( sCD14 ) forms of CD14, thereby markedly increasing host cell sensitivity to endotoxin. LBP efficiently catalyzes the transfer of individual molecules of endotoxin to (s)CD14 only when LBP?endotoxin aggregates are formed in the presence of albumin. In the presence of EDTA, LBP binding promotes further disaggregation of endotoxin. LBP binding does not have such drastic effects under more physiological conditions, but may still induce more subtle topological rearrangements of endotoxin. |
| Reference | Carsten J. Kirschning, et al., 1997, Genomics, Volume 46, Issue 3: 416-25.,J. Weiss, 2003, Biochemical Society Transactions: Volume 31, part 4: 785-790.,RR Schumann, et al., Science, 1990, Vol 249, Issue 4975: 1429-143. |
| URL | https://www.targetmol.com/recombinant-protein/lbp_protein_human_recombinant_his_tag_ |
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