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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02115
- 製品名称
- R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
- タンパク質名
- R-Spondin 3/RSPO3
- Species
- Human
- HOST
- HEK293 Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | CRISTIN1, THSD2, R-spondin 3, PWTSR |
|---|---|
| Characteristics | Measured by its binding ability in a functional ELISA. Immobilized Human RSPO3 His at 2 μg/ml (100 μl/well) can bind Human RNF43 hFc , the EC50 of Human RNF43 hFc is 3.0-12.0 ng/mL. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | - |
| Description | R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify signaling of Wnt3A, Wnt1, and Wnt7A, suggesting that RSPO proteins are general regulators of canonical Wnt signaling. RSPO3/PCP signaling during gastrulation requires Wnt5a and is transduced via Fz7, Dvl, and JNK. RSPO3 functions by inducing Sdc4-dependent, clathrin-mediated endocytosis. RSPO3 is a novel, evolutionarily conserved angiogenic factor in embryogenesis. RSPO3 has a key role in the interaction between chorion and allantois in labyrinthine development. |
| Reference | Kazanskaya O, et al. (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 135(22): 3655-64.,Ohkawara B, et al. (2011) Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis. Dev Cell. 20(3): 303-14.,Kim KA, et al. (2008) R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell. 19(6): 2588-96.,Aoki M, et al. (2007) R-spondin3 is required for mouse placental development. Dev Biol. 301(1): 218-26. |
| URL | https://www.targetmol.com/recombinant-protein/rspo3_protein_human_recombinant_aa_1_146_his_tag_ |
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