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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02078
- 製品名称
- HtrA2/Omi Protein, Human, Recombinant (His)
- タンパク質名
- HtrA2/Omi
- Species
- Human
- HOST
- E. coli
- 100μg: -
- お問い合わせ
Overview
| Synonyms | OMI, HtrA serine peptidase 2, PRSS25, PARK13 |
|---|---|
| Characteristics | Protease activity demonstrated by HtrA2 cleavage of bovine β-casein. Incubation of β-casein at 0.2 mg/mL with Recombinant Human HTRA-2 at 0.02 mg/mL (ratio of 10:1) for 60 minutes at 45℃ in 50 mM Tris, pH 8.0, which results in >95% cleavage of β-casein, as revealed by SDS-PAGE. |
| Endotoxin Level | Please contact us for more information. |
| Purity | 88% |
| Description | Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity or by a BIRC inhibition-independent, caspase-independent, and serine protease activity-dependent mechanism. HTRA2 cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 of HTRA2 seems to be proteolytically inactive. Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) which is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, as well as by a clinically significant response to treatment with levodopa. |
| Reference | Faccio L., et al., 2000, J. Biol. Chem. 275:2581-2588.,Strauss K.M., et al., 2005, Hum. Mol. Genet. 14:2099-2111.,Gray C.W., et al., 2000, Eur. J. Biochem. 267:5699-5710.,Suzuki Y., et al., 2001, Mol. Cell 8:613-621. |
| URL | https://www.targetmol.com/recombinant-protein/htra2_omi_protein_human_recombinant_his_tag_ |
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