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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-02001
- 製品名称
- RTN4 Protein, Human, Recombinant (GST)
- タンパク質名
- RTN4
- Species
- Human
- HOST
- E. coli
- 100μg: -
- お問い合わせ
Overview
| Synonyms | NOGO, Nogo protein, RTN-x, KIAA0886, Reticulon-4, Neuroendocrine-specific protein, Reticulon-5, Neurite outgrowth inhibitor, Neuroendocrine-specific protein C homolog, RTN4, Foocen |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | Please contact us for more information. |
| Purity | - |
| Description | Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 of RTN4 is testis-specific. Reticulon-4 / RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4 / RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 / RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing. |
| Reference | Murayama K.S., et al., 2006, Eur. J. Neurosci. 24: 1237-1244.,Tagami S., et al., 2000, Oncogene 19: 5736-5746.,Yang J., et al., 2000, Cytogenet. Cell Genet. 88:101-102.Prinjha R., et al., 2000, Nature 403: 383-384.,Daub H., et al., 2008, Mol. Cell 31:438-448.Choudhary C., et al., 2009, Science 325: 834-840. |
| URL | https://www.targetmol.com/recombinant-protein/rtn4_protein_human_recombinant_gst_tag_ |
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