IL-21 Protein, Human, Recombinant [TMPY-01963]

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Synonyms	CVID11, IL-21, Za11, interleukin 21
Characteristics	Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 0.4-2 ng/mL.
Endotoxin Level	< 5 EU/mg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 97.3%; SEC-HPLC: 97.0%
Description	IL-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.6 kDa and the accession number is Q9HBE4-1.
Reference	Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10.,Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63.,Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34.,Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96.
URL	https://www.targetmol.com/recombinant-protein/il21_protein_human_recombinant_hplc_verified

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