検索タンパク質、抗体、アッセイキット
タンパク質カタログ
輸入に関する法規制チェックは、御見積のご依頼をいただいた際に行います。
法規制によっては、定価として記載の価格に追加の費用が発生する場合や供給出来ない場合がございますので、あらかじめご了承ください。
- サプライヤー
- TargteMol
- カタログNo.
- TMPY-01958
- 製品名称
- RhoA Protein, Human, Recombinant (His)
- タンパク質名
- RhoA
- Species
- Human
- HOST
- Baculovirus Insect Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | ras homolog family member A, ARHA, RHO12, RHOH12, ARH12 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | > 90 % as determined by SDS-PAGE |
| Description | Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA / ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA / ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA / ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA / ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP. |
| Reference | Yiu G, et al.,2006,?Nat. Rev. Neurosci.?7?(8): 617-27.,Anastasiadis,P.Z. et al., 2000, Nat Cell Biol. 2?(9):637-44.,Kiss C, et al.,1997, Cytogenet. Cell Genet.?79?(3-4): 228-30.,Heo,J. et al.,?2006, Biochemistry. 45?(48):14481-9.,Wang,HR. et al., 2006, Methods Enzymol. 406?:437-47. |
| URL | https://www.targetmol.com/recombinant-protein/rhoa_protein_human_recombinant_his_tag_ |
お問い合わせリスト