IL-21R Protein, Human, Recombinant (His) [TMPY-01934]

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Synonyms	CD360, NILR, interleukin 21 receptor
Characteristics	1. Measured by its ability to bind human IL-21 in a functional ELISA. 2.Measured by its ability to inhibit IL-21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 4-25 ng/mL in the presence of 2ng/mL of recombinant human IL-21.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 95.2%; SEC-HPLC: 90.5%
Description	IL-21R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q9HBE5-1.
Reference	De Totero D, et al. (2006) Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 107(9): 3708-15.,Asao H, et al. (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 167(1): 1-5.,Wu Z, et al. (2005) Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 25(22): 9741-52.
URL	https://www.targetmol.com/recombinant-protein/il21_receptor_protein_human_recombinant_his_tag_hplc_verified

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